There are substantial scientific evidence to show that Alpha S1-Casein Tryptic Hydrolysate helps to improve sleep quality as well as to decrease and modulate stress symptoms naturally.

Study 1: Effects of a Bovine Alpha S1-Casein Tryptic Hydrolysate (CTH) on Sleep Disorder in Japanese General Population

A recent clinical study was conducted in Tokyo on 44 Japanese subjects (men and women aged 25-40) with insomnia by a team of scientists from the Sleep Centre, University Hospital of Geneva, Switzerland, the Laboratoire de NeuroSciences Comportementales, France and the Ashikaga Institute of Technology, Japan. The published study in The Open Sleep Journal (2009;2) showed that Alpha S1-Casein helped a majority of participants to fall asleep faster, as well as significantly improve various aspects of sleep disorders. Results indicated:

  • Improvement in sleep quality after two weeks of supplementation.
  • Decrease in sleep latency after four weeks of supplementation.
  • Decrease in daytime dysfunction after four weeks of supplementation

Study 2: Efficacy of alpha S1-casein hydrolysate on stress-related symptoms in women

The Proclaim study was performed on 63 stressed women (aged 18 to 61) over 30 days. Alpha S1-Casein was particularly efficient on the subjects who demonstrated the highest initial intensity of symptoms, suggesting that this milk peptide has regulating properties on stress-related disorders. Results:

  • A significant greater positive evolution of stress symptoms in 5 different areas was demonstrated in the group taking Alpha S1-Casein vs placebo.

Study 3: Effects of a tryptic hydrolysate from bovine milk alpha S1-casein on hemodynamic responses in healthy human volunteers facing successive mental and physical stress situations

The Necker Hospital study was conducted in Paris among 42 male volunteers (aged 18 to 35) facing acute stress over 2 days. Results:

  • During the stroop test, SBP and DBP responses were signicantly reduced in the alpha S1-casein group compared to the placebo group.
  • After the stress test, blood cortisol level had remained stable in the placebo group while it has decreased significantly in the alpha S1-casein group.

Study 4: Long-term effects of bovine milk alpha S1-casein hydrolysate (PRODIET TM F200) on healthy low and high stress responders.

The CRSSA study was conducted over 30 days with the recommended dose of 150 mg/day of Lactium® on 52 volunteers in perfect health (25 men and 27 women aged 18 to 40, selected at random). The results following the Stroop test showed:

  • a reduction in blood pressure for the group which used Lactium®, the physiological response to stress being an increase in blood pressure.

Study 5: The effect of Lactium® on biathlete training.

The study performed at a Military Base in Quebec in 2004 tested the effect of Alpha S1-Casein on ten national and international biathletes who were subjected to 4 weeks of rigorous training. Results showed:

  • The mean cortisol (stress hormone) level was significantly lower in the athletes taking Alpha S1-Casein, while it was higher in athletes taking placebo, at week 4 compared to the basal level observed during the first week.
  • Alpha S1-Casein can help counter the negative physiological effects caused by the rise of cortisol levels induced by rigorous training and may therefore ensure performance development.

Study 6: Characterization of alpha-casozepine, a tryptic peptide from bovine alpha S1-casein with benzodiazepine-like activity

Study 7: Conformational studies of a benzodiazepine-like peptide in SDS micelles by circular dichroism, 1H NMR and molecular dynamics simulation

Study 8: Two-dimensional 1H-NMR and CD structural analysis in a micellar medium of a bovine Alpha S1-casein fragment having benzodiazepine-like properties.

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